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TitlePyridinyl aminohydantoins as small molecule BACE1 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 2326-2329, Year 2010
Publish dateJan 22, 2010 (structure data deposition date)
AuthorsZhou, P. / Li, Y. / Fan, Y. / Wang, Z. / Chopra, R. / Olland, A. / Hu, Y. / Magolda, R.L. / Pangalos, M. / Reinhart, P.H. ...Zhou, P. / Li, Y. / Fan, Y. / Wang, Z. / Chopra, R. / Olland, A. / Hu, Y. / Magolda, R.L. / Pangalos, M. / Reinhart, P.H. / Turner, M.J. / Bard, J. / Malamas, M.S. / Robichaud, A.J.
External linksBioorg. Med. Chem. Lett. / PubMed:20202842
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3lhg:
Bace1 in complex with the aminohydantoin Compound 4g
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-Z81:
(5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-methyl-5-pyridin-4-yl-3,5-dihydro-4H-imidazol-4-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / inhibitor / aminohydantoin

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