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-Structure paper
Title | Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 2321-2325, Year 2010 |
Publish date | Jan 25, 2010 (structure data deposition date) |
![]() | Tsou, H.R. / MacEwan, G. / Birnberg, G. / Grosu, G. / Bursavich, M.G. / Bard, J. / Brooijmans, N. / Toral-Barza, L. / Hollander, I. / Mansour, T.S. ...Tsou, H.R. / MacEwan, G. / Birnberg, G. / Grosu, G. / Bursavich, M.G. / Bard, J. / Brooijmans, N. / Toral-Barza, L. / Hollander, I. / Mansour, T.S. / Ayral-Kaloustian, S. / Yu, K. |
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Methods | X-ray diffraction |
Resolution | 2.43 Å |
Structure data | ![]() PDB-3lj3: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-WYE: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / ATP-binding / Kinase / Nucleotide-binding |