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TitleSupramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 11755-11759, Year 2010
Publish dateNov 17, 2009 (structure data deposition date)
AuthorsPhillips, N.B. / Wan, Z.L. / Whittaker, L. / Hu, S.Q. / Huang, K. / Hua, Q.X. / Whittaker, J. / Ismail-Beigi, F. / Weiss, M.A.
External linksJ. Biol. Chem. / PubMed:20181952
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3kq6:
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-IPH:
PHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / zinc-binding site / long-acting insulin analog / receptor binding / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Disulfide bond / Glucose metabolism / Pharmaceutical / Secreted

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