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-Structure paper
Title | Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies. |
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Journal, issue, pages | J. Med. Chem., Year 2010 |
Publish date | Jul 28, 2009 (structure data deposition date) |
Authors | Gitto, R. / Agnello, S. / Ferro, S. / De Luca, L. / Vullo, D. / Brynda, J. / Mader, P. / Supuran, C.T. / Chimirri, A. |
External links | J. Med. Chem. / PubMed:20170095 |
Methods | X-ray diffraction |
Resolution | 1.65 Å |
Structure data | PDB-3igp: |
Chemicals | ChemComp-ZN: ChemComp-DT7: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | LYASE / carbonic anhydrase inhibitors / isoquinolines / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc |