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TitleMutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 11948-11957, Year 2010
Publish dateDec 4, 2009 (structure data deposition date)
AuthorsLuscieti, S. / Santambrogio, P. / Langlois d'Estaintot, B. / Granier, T. / Cozzi, A. / Poli, M. / Gallois, B. / Finazzi, D. / Cattaneo, A. / Levi, S. / Arosio, P.
External linksJ. Biol. Chem. / PubMed:20159981
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-3kxu:
Crystal structure of human ferritin FTL498InsTC pathogenic mutant
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-CD:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / IRON STORAGE PROTEIN / DISORDER / Iron

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