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TitleOptimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing.
Journal, issue, pagesBioorg. Med. Chem., Vol. 18, Page 1844-, Year 2010
Publish dateAug 3, 2009 (structure data deposition date)
AuthorsBrasca, M.G. / Albanese, C. / Alzani, R. / Amici, R. / Avanzi, N. / Ballinari, D. / Bischoff, J. / Borghi, D. / Casale, E. / Croci, V. ...Brasca, M.G. / Albanese, C. / Alzani, R. / Amici, R. / Avanzi, N. / Ballinari, D. / Bischoff, J. / Borghi, D. / Casale, E. / Croci, V. / Fiorentini, F. / Isacchi, A. / Mercurio, C. / Nesi, M. / Orsini, P. / Pastori, W. / Pesenti, E. / Pevarello, P. / Roussel, P. / Varasi, M. / Volpi, D. / Vulpetti, A. / Ciomei, M.
External linksBioorg. Med. Chem. / PubMed:20153204
MethodsX-ray diffraction
Resolution2.51 Å
Structure data

PDB-2wpa:
Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-889:
N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / SERINE/THREONINE-PROTEIN 2 KINASE / CYCLIN / MITOSIS / TRANSFERASE / ATP-BINDING / PHOSPHOPROTEIN

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