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Title | Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-Aryl-4,5-Dihydrothiazolo[4,5-H]Quinazolin-8-Amines as Ring-Constrained 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Cyclin-Dependent Kinase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 2136-, Year 2010 |
Publish date | Dec 31, 2009 (structure data deposition date) |
Authors | Mcintyre, N.A. / Mcinnes, C. / Griffiths, G. / Barnett, A.L. / Kontopidis, G. / Slawin, A.M.Z. / Jackson, W. / Thomas, M. / Zheleva, D.I. / Wang, S. ...Mcintyre, N.A. / Mcinnes, C. / Griffiths, G. / Barnett, A.L. / Kontopidis, G. / Slawin, A.M.Z. / Jackson, W. / Thomas, M. / Zheleva, D.I. / Wang, S. / Blake, D.G. / Westwood, N.J. / Fischer, P.M. |
External links | J. Med. Chem. / PubMed:20146435 |
Methods | X-ray diffraction |
Resolution | 2.75 Å |
Structure data | PDB-2x1n: |
Chemicals | ChemComp-X1N: ChemComp-HOH: |
Source |
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Keywords | CELL CYCLE / INHIBITION / TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / CELL DIVISION |