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TitleChemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
Journal, issue, pagesNat. Chem. Biol., Vol. 6, Page 133-139, Year 2010
Publish dateMay 20, 2009 (structure data deposition date)
AuthorsChoi, S. / Connelly, S. / Reixach, N. / Wilson, I.A. / Kelly, J.W.
External linksNat. Chem. Biol. / PubMed:20081815
MethodsX-ray diffraction
Resolution1.34 Å
Structure data

PDB-3hj0:
Transthyretin in complex with a covalent small molecule kinetic stabilizer
Method: X-RAY DIFFRACTION / Resolution: 1.34 Å

Chemicals

ChemComp-A93:
4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / Growth Factor / Amyloid / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Polyneuropathy / Retinol-binding / Secreted / Thyroid hormone / Transport / Vitamin A

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