+Search query
-Structure paper
Title | The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1). |
---|---|
Journal, issue, pages | Eur. J. Med. Chem., Vol. 45, Page 1379-1386, Year 2010 |
Publish date | Aug 14, 2009 (structure data deposition date) |
![]() | Nittoli, T. / Dushin, R.G. / Ingalls, C. / Cheung, K. / Floyd, M.B. / Fraser, H. / Olland, A. / Hu, Y. / Grosu, G. / Han, X. ...Nittoli, T. / Dushin, R.G. / Ingalls, C. / Cheung, K. / Floyd, M.B. / Fraser, H. / Olland, A. / Hu, Y. / Grosu, G. / Han, X. / Arndt, K. / Guo, B. / Wissner, A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.4 Å |
Structure data | ![]() PDB-3ion: ![]() PDB-3iop: |
Chemicals | ![]() ChemComp-8H1: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-8I1: |
Source |
|
![]() | TRANSFERASE / PDK-1 / inhibitor / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |