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TitleMutations abrogating VP35 interaction with double-stranded RNA render ebola virus avirulent in guinea pigs.
Journal, issue, pagesJ. Virol., Vol. 84, Page 3004-3015, Year 2010
Publish dateDec 14, 2009 (structure data deposition date)
AuthorsPrins, K.C. / Delpeut, S. / Leung, D.W. / Reynard, O. / Volchkova, V.A. / Reid, S.P. / Ramanan, P. / Cardenas, W.B. / Amarasinghe, G.K. / Volchkov, V.E. / Basler, C.F.
External linksJ. Virol. / PubMed:20071589
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-3l29:
Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • zaire ebolavirus
KeywordsRNA BINDING PROTEIN / RNA BINDING DOMAIN / INTERFERON ANTIVIRAL EVASION / RNA REPLICATION / TRANSCRIPTION / Host cytoplasm / Interferon antiviral system evasion / RNA-binding / Virion

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