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-Structure paper
Title | Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. |
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Journal, issue, pages | Protein Sci., Vol. 19, Page 429-439, Year 2010 |
Publish date | Feb 25, 2009 (structure data deposition date) |
Authors | Marcotte, D.J. / Liu, Y.T. / Arduini, R.M. / Hession, C.A. / Miatkowski, K. / Wildes, C.P. / Cullen, P.F. / Hong, V. / Hopkins, B.T. / Mertsching, E. ...Marcotte, D.J. / Liu, Y.T. / Arduini, R.M. / Hession, C.A. / Miatkowski, K. / Wildes, C.P. / Cullen, P.F. / Hong, V. / Hopkins, B.T. / Mertsching, E. / Jenkins, T.J. / Romanowski, M.J. / Baker, D.P. / Silvian, L.F. |
External links | Protein Sci. / PubMed:20052711 |
Methods | X-ray diffraction |
Resolution | 1.6 - 1.94 Å |
Structure data | PDB-3gen: PDB-3k54: |
Chemicals | ChemComp-B43: ChemComp-HOH: ChemComp-1N1: |
Source |
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Keywords | TRANSFERASE / Bruton's tyrosine kinase / 4-Amino-5-(4-phenoxyphenyl)-5H-pyrrolo[3 / 2-d]pyrimidin-7-yl-cyclopentane / TEC-family / complex / Acetylation / ATP-binding / Cytoplasm / Disease mutation / Kinase / Membrane / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / SH2 domain / SH3 domain / Tyrosine-protein kinase / Zinc / Zinc-finger / BTK / Dasatinib |