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-Structure paper
Title | Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 18, Page 630-639, Year 2010 |
Publish date | Aug 11, 2009 (structure data deposition date) |
Authors | Malamas, M.S. / Barnes, K. / Johnson, M. / Hui, Y. / Zhou, P. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. / Chopra, R. ...Malamas, M.S. / Barnes, K. / Johnson, M. / Hui, Y. / Zhou, P. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. / Chopra, R. / Olland, A. / Bard, J. / Pangalos, M. / Reinhart, P. / Robichaud, A.J. |
External links | Bioorg. Med. Chem. / PubMed:20045648 |
Methods | X-ray diffraction |
Resolution | 2 - 2.3 Å |
Structure data | PDB-3in3: PDB-3in4: |
Chemicals | ChemComp-472: ChemComp-HOH: ChemComp-BX2: |
Source |
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Keywords | HYDROLASE / bace1 / inhibitor / Alternative splicing / Aspartyl protease / Disulfide bond / Glycoprotein / Membrane / Polymorphism / Protease / Transmembrane / Zymogen / bace-1 |