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TitleSynthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
Journal, issue, pagesEur. J. Med. Chem., Vol. 45, Page 870-882, Year 2010
Publish dateSep 4, 2009 (structure data deposition date)
AuthorsWangsell, F. / Gustafsson, K. / Kvarnstrom, I. / Borkakoti, N. / Edlund, M. / Jansson, K. / Lindberg, J. / Hallberg, A. / Rosenquist, A. / Samuelsson, B.
External linksEur. J. Med. Chem. / PubMed:20036448
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3ixk:
Potent beta-secretase 1 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-929:
N-[(2S,3S,5R)-1-[(3,5-difluorophenyl)methoxy]-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(phenylmethylamino)butan-2-yl]amino]-6-oxo-hexan-2-yl]-5-(methyl-methylsulfonyl-amino)-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / BACE / beta-secretase / statine / inhibitor / aspartyl protease / glycoprotein / membrane / protease / transmembrane / ZYMOGEN / Disulfide bond

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