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TitleThe coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 850-854, Year 2010
Publish dateJul 23, 2009 (structure data deposition date)
AuthorsTemperini, C. / Innocenti, A. / Scozzafava, A. / Parkkila, S. / Supuran, C.T.
External linksJ. Med. Chem. / PubMed:20028100
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3ieo:
The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HG:
Unknown entry

ChemComp-AMJ:
N~2~-acetyl-N-benzyl-O-methyl-L-serinamide

ChemComp-BEZ:
BENZOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE/LYASE INHIBITOR / carbonic anhydrase / antiepilectic / Disease mutation / Lyase / Metal-binding / LYASE-LYASE INHIBITOR complex

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