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-Structure paper
Title | Heme Oxygenase Inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. |
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Journal, issue, pages | Chem. Biol. Drug Des., Vol. 75, Page 68-90, Year 2010 |
Publish date | Oct 5, 2009 (structure data deposition date) |
Authors | Roman, G. / Rahman, M.N. / Vukomanovic, D. / Jia, Z. / Nakatsu, K. / Szarek, W.A. |
External links | Chem. Biol. Drug Des. / PubMed:19954435 |
Methods | X-ray diffraction |
Resolution | 2.17 Å |
Structure data | PDB-3k4f: |
Chemicals | ChemComp-HEM: ChemComp-Q86: ChemComp-HEZ: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / HEME OXYGENASE-1 INHIBITOR COMPLEX / alpha helices / Endoplasmic reticulum / Heme / Iron / Metal-binding / Microsome / Phosphoprotein / Polymorphism |