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Structure paper

TitleKinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae
Journal, issue, pagesBiochemistry, Vol. 49, Page 195-206, Year 2010
Publish dateSep 3, 2009 (structure data deposition date)
AuthorsLee, J. / Yennawar, N.H. / Gam, J. / Benkovic, S.J.
External linksBiochemistry / PubMed:19950924
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-3ix9:
Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MTX:
METHOTREXATE / chemotherapy*YM

ChemComp-HOH:
WATER

Source
  • streptococcus pneumoniae (bacteria)
KeywordsOXIDOREDUCTASE / Central beta sheet surrounded by 4 alpha helices

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