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Title | 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 330-333, Year 2010 |
Publish date | Oct 16, 2009 (structure data deposition date) |
Authors | Argiriadi, M.A. / Ericsson, A.M. / Harris, C.M. / Banach, D.L. / Borhani, D.W. / Calderwood, D.J. / Demers, M.D. / Dimauro, J. / Dixon, R.W. / Hardman, J. ...Argiriadi, M.A. / Ericsson, A.M. / Harris, C.M. / Banach, D.L. / Borhani, D.W. / Calderwood, D.J. / Demers, M.D. / Dimauro, J. / Dixon, R.W. / Hardman, J. / Kwak, S. / Li, B. / Mankovich, J.A. / Marcotte, D. / Mullen, K.D. / Ni, B. / Pietras, M. / Sadhukhan, R. / Sousa, S. / Tomlinson, M.J. / Wang, L. / Xiang, T. / Talanian, R.V. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19919896 |
Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | PDB-3ka0: PDB-3kc3: |
Chemicals | ChemComp-MK3: ChemComp-HOH: ChemComp-MK2: |
Source |
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Keywords | TRANSFERASE / MAPKAP-K2 / MK2 / TNFalpha / diaminopyrimidine / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |