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Structure paper

TitleStructure and Functional Characterization of the Atypical Human Kinase Haspin.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 20198-, Year 2009
Publish dateMay 30, 2008 (structure data deposition date)
AuthorsEswaran, J. / Patnaik, D. / Filippakopoulos, P. / Wang, F. / Stein, R.L. / Murray, J.W. / Higgins, J.M.G. / Knapp, S.
External linksProc. Natl. Acad. Sci. USA / PubMed:19918057
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-2vuw:
Structure of human haspin kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3dlz:
Crystal structure of human haspin in complex with AMP
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-3iq7:
Crystal Structure of human Haspin in complex with 5-Iodotubercidin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-5ID:
(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL

ChemComp-NI:
NICKEL (II) ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CELL CYCLE / CASP8 / NUCLEOTIDE BINDING / Haspin / Germ cell associated 2 / Haploid germ cell specific nuclear protein kinase / SGC / Structural Genomics Consortium / ATP-binding / Chromatin regulator / Magnesium / Nucleotide-binding / Nucleus / Phosphoprotein / Serine/threonine-protein kinase / Kinase

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