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Structure paper

TitleStructure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.
Journal, issue, pagesScience, Vol. 326, Page 1707-, Year 2009
Publish dateSep 16, 2009 (structure data deposition date)
AuthorsZeqiraj, E. / Filippi, B.M. / Deak, M. / Alessi, D.R. / Van Aalten, D.M.F.
External linksScience / PubMed:19892943
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-2wtk:
Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/METAL-BINDING PROTEIN / TRANSFERASE-METAL-BINDING PROTEIN COMPLEX / TRANSFERASE METAL-BINDING PROTEIN COMPLEX / KINASE / NUCLEUS / SERINE/THREONINE-PROTEIN KINASE / PSEUDOKINASE / PHOSPHOPROTEIN / SIGNAL TRANSDUCTION / TRANSFERASE / NUCLEOTIDE-BINDING

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