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-Structure paper
Title | Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5217-5227, Year 2009 |
Publish date | May 5, 2009 (structure data deposition date) |
![]() | Ontoria, J.M. / Rydberg, E.H. / Di Marco, S. / Tomei, L. / Attenni, B. / Malancona, S. / Martin Hernando, J.I. / Gennari, N. / Koch, U. / Narjes, F. ...Ontoria, J.M. / Rydberg, E.H. / Di Marco, S. / Tomei, L. / Attenni, B. / Malancona, S. / Martin Hernando, J.I. / Gennari, N. / Koch, U. / Narjes, F. / Rowley, M. / Summa, V. / Carroll, S.S. / Olsen, D.B. / De Francesco, R. / Altamura, S. / Migliaccio, G. / Carfi, A. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-2who: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-VGI: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / RNA REPLICATION / ENVELOPE PROTEIN / HEPATITIS C VIRUS / ENDOPLASMIC RETICULUM / NON NUCLEOSIDE INHIBITOR / VIRAL PROTEIN / METAL-BINDING / TRANSMEMBRANE / POLYMERASE / ATP-BINDING / GENOTYPE 1B / RNA-BINDING / RNA-DEPENDENT RNA POLYMERASE / NNI / HCV / NS5B / MEMBRANE / HELICASE / HYDROLASE / NUCLEOTIDE-BINDING / ALLOSTERIC INHIBITOR / RNA-DIRECTED RNA POLYMERASE |