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Structure paper

TitleMolecular basis for insulin fibril assembly.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 18990-18995, Year 2009
Publish dateJun 22, 2009 (structure data deposition date)
AuthorsIvanova, M.I. / Sievers, S.A. / Sawaya, M.R. / Wall, J.S. / Eisenberg, D.
External linksProc. Natl. Acad. Sci. USA / PubMed:19864624
MethodsX-ray diffraction
Resolution1 Å
Structure data

PDB-3hyd:
LVEALYL peptide derived from human insulin chain B, residues 11-17
Method: X-RAY DIFFRACTION / Resolution: 1 Å

Chemicals

ChemComp-HOH:
WATER

KeywordsPROTEIN FIBRIL / amyloid-like protofibril / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Disulfide bond / Glucose metabolism / Hormone / Pharmaceutical / Secreted

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