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TitleNon-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 6519-6523, Year 2009
Publish dateJul 31, 2009 (structure data deposition date)
AuthorsBerger, D.M. / Torres, N. / Dutia, M. / Powell, D. / Ciszewski, G. / Gopalsamy, A. / Levin, J.I. / Kim, K.H. / Xu, W. / Wilhelm, J. ...Berger, D.M. / Torres, N. / Dutia, M. / Powell, D. / Ciszewski, G. / Gopalsamy, A. / Levin, J.I. / Kim, K.H. / Xu, W. / Wilhelm, J. / Hu, Y. / Collins, K. / Feldberg, L. / Kim, S. / Frommer, E. / Wojciechowicz, D. / Mallon, R.
External linksBioorg. Med. Chem. Lett. / PubMed:19864136
MethodsX-ray diffraction
Resolution2.79 Å
Structure data

PDB-3ii5:
The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-831:
N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / B-Raf / Kinase / protein-inhibitor complex / Acetylation / ATP-binding / Cardiomyopathy / Cytoplasm / Disease mutation / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Phosphoprotein / Polymorphism / Proto-oncogene / Serine/threonine-protein kinase / Zinc / Zinc-finger

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