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TitleDiscovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 7044-7053, Year 2009
Publish dateSep 23, 2009 (structure data deposition date)
AuthorsAllen, J.G. / Bourbeau, M.P. / Wohlhieter, G.E. / Bartberger, M.D. / Michelsen, K. / Hungate, R. / Gadwood, R.C. / Gaston, R.D. / Evans, B. / Mann, L.W. ...Allen, J.G. / Bourbeau, M.P. / Wohlhieter, G.E. / Bartberger, M.D. / Michelsen, K. / Hungate, R. / Gadwood, R.C. / Gaston, R.D. / Evans, B. / Mann, L.W. / Matison, M.E. / Schneider, S. / Huang, X. / Yu, D. / Andrews, P.S. / Reichelt, A. / Long, A.M. / Yakowec, P. / Yang, E.Y. / Lee, T.A. / Oliner, J.D.
External linksJ. Med. Chem. / PubMed:19856920
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3jzk:
crystal structure of MDM2 with chromenotriazolopyrimidine 1
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-YIN:
(6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / MDM2 / p53 / inhibitor / Alternative splicing / Cytoplasm / Host-virus interaction / Metal-binding / Nucleus / Phosphoprotein / Proto-oncogene / Ubl conjugation / Ubl conjugation pathway / Zinc / Zinc-finger

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