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-Structure paper
Title | Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 6565-6570, Year 2009 |
Publish date | Sep 30, 2009 (structure data deposition date) |
Authors | Steele, R.M. / Benedini, F. / Biondi, S. / Borghi, V. / Carzaniga, L. / Impagnatiello, F. / Miglietta, D. / Chong, W.K. / Rajapakse, R. / Cecchi, A. ...Steele, R.M. / Benedini, F. / Biondi, S. / Borghi, V. / Carzaniga, L. / Impagnatiello, F. / Miglietta, D. / Chong, W.K. / Rajapakse, R. / Cecchi, A. / Temperini, C. / Supuran, C.T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19854054 |
Methods | X-ray diffraction |
Resolution | 1.98 Å |
Structure data | PDB-3k2f: |
Chemicals | ChemComp-ZN: ChemComp-HG: ChemComp-NKX: ChemComp-HOH: |
Keywords | LYASE / carbonic anhydrase / NO-donating agent / antiglaucoma drug / sulfonamide / Xray crystallography / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc |