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TitleCrystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
Journal, issue, pagesPLoS ONE, Vol. 4, Page e7112-e7112, Year 2009
Publish dateJun 30, 2006 (structure data deposition date)
AuthorsBullock, A.N. / Russo, S. / Amos, A. / Pagano, N. / Bregman, H. / Debreczeni, J.E. / Lee, W.H. / von Delft, F. / Meggers, E. / Knapp, S.
External linksPLoS ONE / PubMed:19841674
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-2iwi:
CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HB1:
RUTHENIUM-PYRIDOCARBAZOLE-1

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / PIM2 / KINASE / CANCER / LEUKEMIA / ATP-BINDING / PROTO-ONCOGENE / PHOSPHORYLATION

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