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Title3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3
Journal, issue, pagesBioorg. Med. Chem., Vol. 17, Page 7755-7768, Year 2009
Publish dateApr 9, 2009 (structure data deposition date)
AuthorsHavran, L.M. / Chong, D.C. / Childers, W.E. / Dollings, P.J. / Dietrich, A. / Harrison, B.L. / Marathias, V. / Tawa, G. / Aulabaugh, A. / Cowling, R. ...Havran, L.M. / Chong, D.C. / Childers, W.E. / Dollings, P.J. / Dietrich, A. / Harrison, B.L. / Marathias, V. / Tawa, G. / Aulabaugh, A. / Cowling, R. / Kapoor, B. / Xu, W. / Mosyak, L. / Moy, F. / Hum, W.T. / Wood, A. / Robichaud, A.J.
External linksBioorg. Med. Chem. / PubMed:19836248
MethodsX-ray diffraction
Resolution1.997 Å
Structure data

PDB-3h0e:
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3
Method: X-RAY DIFFRACTION / Resolution: 1.997 Å

Chemicals

ChemComp-H0E:
(10S)-3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Caspase-3 / protein-inhibitor complex / apoptosis / Cytoplasm / Phosphoprotein / Polymorphism / Protease / S-nitrosylation / Thiol protease / Zymogen

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