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Structure paper

TitleApamin as a template for structure-based rational design of potent peptide activators of p53.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 48, Page 8712-8715, Year 2009
Publish dateAug 31, 2009 (structure data deposition date)
AuthorsLi, C. / Pazgier, M. / Liu, M. / Lu, W.Y. / Lu, W.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:19827079
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-3iux:
Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

KeywordsLIGASE / MDM2 / p53 binding domain / peptide activator of p53 / Host-virus interaction / Metal-binding / Nucleus / Phosphoprotein / Proto-oncogene / Ubl conjugation pathway / Zinc-finger

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