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Title | Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 106, Page 18114-18119, Year 2009 |
Publish date | Sep 29, 2009 (structure data deposition date) |
![]() | Biggadike, K. / Bledsoe, R.K. / Coe, D.M. / Cooper, T.W. / House, D. / Iannone, M.A. / Macdonald, S.J. / Madauss, K.P. / McLay, I.M. / Shipley, T.J. ...Biggadike, K. / Bledsoe, R.K. / Coe, D.M. / Cooper, T.W. / House, D. / Iannone, M.A. / Macdonald, S.J. / Madauss, K.P. / McLay, I.M. / Shipley, T.J. / Taylor, S.J. / Tran, T.B. / Uings, I.J. / Weller, V. / Williams, S.P. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 3 Å |
Structure data | ![]() PDB-3k22: ![]() PDB-3k23: |
Chemicals | ![]() ChemComp-JZS: ![]() ChemComp-JZR: ![]() ChemComp-HOH: ![]() ChemComp-JZN: |
Source |
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![]() | TRANSCRIPTION / Glucocorticoid Receptor / Steroid Hormone Receptor / Nuclear Receptor / GR / glucocorticoids / alpha helical sandwich / meta-channel / Alternative initiation / Chromatin regulator / Disease mutation / DNA-binding / Isopeptide bond / Lipid-binding / Metal-binding / Nucleus / Phosphoprotein / Pseudohermaphroditism / Receptor / Steroid-binding / Transcription regulation / Zinc-finger / Activator |