+Search query
-Structure paper
Title | Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 6386-6391, Year 2009 |
Publish date | Sep 1, 2009 (structure data deposition date) |
Authors | Sealy, J.M. / Truong, A.P. / Tso, L. / Probst, G.D. / Aquino, J. / Hom, R.K. / Jagodzinska, B.M. / Dressen, D. / Wone, D.W. / Brogley, L. ...Sealy, J.M. / Truong, A.P. / Tso, L. / Probst, G.D. / Aquino, J. / Hom, R.K. / Jagodzinska, B.M. / Dressen, D. / Wone, D.W. / Brogley, L. / John, V. / Tung, J.S. / Pleiss, M.A. / Tucker, J.A. / Konradi, A.W. / Dappen, M.S. / Toth, G. / Pan, H. / Ruslim, L. / Miller, J. / Bova, M.P. / Sinha, S. / Quinn, K.P. / Sauer, J.M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19811916 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.2 Å |
Structure data | PDB-3ivh: PDB-3ivi: |
Chemicals | ChemComp-1LI: ChemComp-HOH: ChemComp-SO4: ChemComp-GOL: ChemComp-2LI: |
Source |
|
Keywords | HYDROLASE / aspartyl protease / BACE-1 inhibitors / Alzheimer's disease / structure-based drug design / Disulfide bond / Glycoprotein / Membrane / Protease / Transmembrane / Zymogen |