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-Structure paper
Title | 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 6047-6052, Year 2009 |
Publish date | Apr 4, 2009 (structure data deposition date) |
Authors | Ellis, D.A. / Blazel, J.K. / Tran, C.V. / Ruebsam, F. / Murphy, D.E. / Li, L.S. / Zhao, J. / Zhou, Y. / McGuire, H.M. / Xiang, A.X. ...Ellis, D.A. / Blazel, J.K. / Tran, C.V. / Ruebsam, F. / Murphy, D.E. / Li, L.S. / Zhao, J. / Zhou, Y. / McGuire, H.M. / Xiang, A.X. / Webber, S.E. / Zhao, Q. / Han, Q. / Kissinger, C.R. / Lardy, M. / Gobbi, A. / Showalter, R.E. / Shah, A.M. / Tsan, M. / Patel, R.A. / LeBrun, L.A. / Kamran, R. / Bartkowski, D.M. / Nolan, T.G. / Norris, D.A. / Sergeeva, M.V. / Kirkovsky, L. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19796938 |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.6 Å |
Structure data | PDB-3gyn: PDB-3igv: |
Chemicals | ChemComp-B42: ChemComp-HOH: ChemComp-B80: |
Source |
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Keywords | TRANSFERASE / PROTEIN-LIGAND COMPLEX / RNA REPLICATION / RNA-BINDING / RNA-DIRECTED RNA POLYMERASE / METAL-BINDING / NUCLEOTIDE-BINDING / NUCLEOTIDYLTRANSFERASE / TRANSCRIPTION / Acetylation / Apoptosis / ATP-binding / Capsid protein / Cell membrane / Cytoplasm / Disulfide bond / Endoplasmic reticulum / Envelope protein / Fusion protein / Glycoprotein / Helicase / Host-virus interaction / Hydrolase / Interferon antiviral system evasion / Lipid droplet / Lipoprotein / Membrane / Mitochondrion / Multifunctional enzyme / Nucleus / Oncogene / Palmitate / Phosphoprotein / Protease / Ribonucleoprotein / Secreted / Serine protease / SH3-binding / Thiol protease / Transcription regulation / Transmembrane / Ubl conjugation / Viral nucleoprotein / Virion / Zinc / ANTIVIRAL / METAL BINDING |