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-Structure paper
Title | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5781-5784, Year 2009 |
Publish date | Jun 22, 2009 (structure data deposition date) |
![]() | Kirschberg, T.A. / Balakrishnan, M. / Squires, N.H. / Barnes, T. / Brendza, K.M. / Chen, X. / Eisenberg, E.J. / Jin, W. / Kutty, N. / Leavitt, S. ...Kirschberg, T.A. / Balakrishnan, M. / Squires, N.H. / Barnes, T. / Brendza, K.M. / Chen, X. / Eisenberg, E.J. / Jin, W. / Kutty, N. / Leavitt, S. / Liclican, A. / Liu, Q. / Liu, X. / Mak, J. / Perry, J.K. / Wang, M. / Watkins, W.J. / Lansdon, E.B. |
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Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-3hyf: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-ACT: ![]() ChemComp-GOL: ![]() ChemComp-ON1: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / RNase H / HIV-1 / di-valent metal nucleic acid cleavage mechanism / di-valent metal coordination / Aspartyl protease / DNA integration / DNA recombination / Endonuclease / Multifunctional enzyme / Nuclease / Nucleotidyltransferase / Protease / RNA-directed DNA polymerase / Transferase / Magnesium / Metal-binding |