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TitlePyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 6131-6134, Year 2009
Publish dateJul 22, 2009 (structure data deposition date)
AuthorsAmeriks, M.K. / Axe, F.U. / Bembenek, S.D. / Edwards, J.P. / Gu, Y. / Karlsson, L. / Randal, M. / Sun, S. / Thurmond, R.L. / Zhu, J.
External linksBioorg. Med. Chem. Lett. / PubMed:19773165
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-3iej:
Pyrazole-based Cathepsin S Inhibitors with Arylalkynes as P1 Binding Elements
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-599:
2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / CATHEPSIN S / Disulfide bond / Glycoprotein / Lysosome / Polymorphism / Protease / Thiol protease / Zymogen

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