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-Structure paper
Title | Selective inhibitors of the mutant B-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 6189-6192, Year 2009 |
Publish date | Jul 21, 2009 (structure data deposition date) |
![]() | Smith, A.L. / Demorin, F.F. / Paras, N.A. / Huang, Q. / Petkus, J.K. / Doherty, E.M. / Nixey, T. / Kim, J.L. / Whittington, D.A. / Epstein, L.F. ...Smith, A.L. / Demorin, F.F. / Paras, N.A. / Huang, Q. / Petkus, J.K. / Doherty, E.M. / Nixey, T. / Kim, J.L. / Whittington, D.A. / Epstein, L.F. / Lee, M.R. / Rose, M.J. / Babij, C. / Fernando, M. / Hess, K. / Le, Q. / Beltran, P. / Carnahan, J. |
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Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | ![]() PDB-3idp: |
Chemicals | ![]() ChemComp-L1E: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / oncogene / ATP-binding / DFG-out / Cardiomyopathy / Disease mutation / Kinase / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Phosphoprotein / Proto-oncogene / Serine/threonine-protein kinase / Zinc-finger |