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-Structure paper
Title | Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 5851-5856, Year 2009 |
Publish date | Jun 3, 2009 (structure data deposition date) |
Authors | Selness, S.R. / Devraj, R.V. / Monahan, J.B. / Boehm, T.L. / Walker, J.K. / Devadas, B. / Durley, R.C. / Kurumbail, R. / Shieh, H. / Xing, L. ...Selness, S.R. / Devraj, R.V. / Monahan, J.B. / Boehm, T.L. / Walker, J.K. / Devadas, B. / Durley, R.C. / Kurumbail, R. / Shieh, H. / Xing, L. / Hepperle, M. / Rucker, P.V. / Jerome, K.D. / Benson, A.G. / Marrufo, L.D. / Madsen, H.M. / Hitchcock, J. / Owen, T.J. / Christie, L. / Promo, M.A. / Hickory, B.S. / Alvira, E. / Naing, W. / Blevis-Bal, R. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19751974 |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.3 Å |
Structure data | PDB-3hp2: PDB-3hp5: |
Chemicals | ChemComp-P36: ChemComp-I46: ChemComp-HOH: ChemComp-52P: |
Source |
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Keywords | TRANSFERASE / two lobes / two ligands / two binding sites / ATP site and distal site / peptide flip / ATP-binding / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Serine/threonine-protein kinase / three ligands / three binding sites / distal and extra sites. peptide flip |