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TitleCharacterization of Gene-Activated Human Acid-Beta-Glucosidase: Crystal Structure, Glycan Composition and Internalization Into Macrophages.
Journal, issue, pagesGlycobiology, Vol. 20, Page 24-, Year 2010
Publish dateJun 15, 2009 (structure data deposition date)
AuthorsBrumshtein, B. / Salinas, P. / Peterson, B. / Chan, V. / Silman, I. / Sussman, J.L. / Savickas, P.J. / Robinson, G.S. / Futerman, A.H.
External linksGlycobiology / PubMed:19741058
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-2wkl:
Velaglucerase alfa
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ALTERNATIVE INITIATION / SPHINGOLIPID METABOLISM / MEMBRANE / LYSOSOME / ICHTHYOSIS / N-NONYL-DEOXYNOJIRIMYCIN / N-NONYL-DEOXYNOJIRIMYCIN ALTERNATIVE INITIATION / DISULFIDE BOND / PHARMACEUTICAL / GAUCHER DISEASE / GLYCOSIDASE / POLYMORPHISM / GLYCOPROTEIN / ALTERNATIVE SPLICING / ACID-BETA-GLUCOSIDASE / LIPID METABOLISM / DISEASE MUTATION / VELAGLUCERASE ALFA

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