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Structure paper

TitleRapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5).
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 7901-, Year 2009
Publish dateJul 28, 2009 (structure data deposition date)
AuthorsGoldberg, F.W. / Ward, R.A. / Powell, S.J. / Debreczeni, J.E. / Norman, R.A. / Roberts, N.J. / Dishington, A.P. / Gingell, H.J. / Wickson, K.F. / Roberts, A.L.
External linksJ. Med. Chem. / PubMed:19736928
MethodsX-ray diffraction
Resolution1.85 - 2.3 Å
Structure data

PDB-2wot:
ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2wou:
ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZZG:
4-[(5,6-DIMETHYL-2,2'-BIPYRIDIN-3-YL)OXY]-N-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-2-AMINE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-ZZF:
4-({4-[(2,6-DIMETHYLPYRIDIN-3-YL)OXY]PYRIDIN-2-YL}AMINO)BENZENESULFONAMIDE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ALK5 / KINASE / MEMBRANE / RECEPTOR / MANGANESE / SERINE/THREONINE-PROTEIN KINASE / KINASE INHIBITOR / DISEASE MUTATION / CRANIOSYNOSTOSIS / NUCLEOTIDE-BINDING / TGF BETA TYPE I RECEPTOR / PHOSPHOPROTEIN / DISULFIDE BOND / AORTIC ANEURYSM / GLYCOPROTEIN / METAL-BINDING / TRANSMEMBRANE / ATP-BINDING / ALK

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