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-Structure paper
Title | Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5990-5998, Year 2009 |
Publish date | Jul 16, 2009 (structure data deposition date) |
Authors | Vitale, R.M. / Alterio, V. / Innocenti, A. / Winum, J.-Y. / Monti, S.M. / De Simone, G. / Supuran, C.T. |
External links | J. Med. Chem. / PubMed:19731956 |
Methods | X-ray diffraction |
Resolution | 1.41 - 2.2 Å |
Structure data | PDB-3ibi: PDB-3ibl: PDB-3ibn: PDB-3ibu: |
Chemicals | ChemComp-ZN: ChemComp-BOW: ChemComp-HGB: ChemComp-CL: ChemComp-HOH: ChemComp-O59: ChemComp-O60: ChemComp-O48: |
Source |
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Keywords | LYASE/LYASE INHIBITOR / CARBONIC ANHYDRASE II / PROTEIN-INHIBITOR COMPLEX / ALIPHATIC SULFAMATE INHIBITOR / Disease mutation / Metal-binding / LYASE-LYASE INHIBITOR complex / ALIPHATIC BIS-SULFAMATE INHIBITOR |