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Structure paper

TitleAre the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?
Journal, issue, pagesChembiochem, Vol. 10, Page 2348-2353, Year 2009
Publish dateJul 13, 2009 (structure data deposition date)
AuthorsHay, S. / Evans, R.M. / Levy, C. / Loveridge, E.J. / Wang, X. / Leys, D. / Allemann, R.K. / Scrutton, N.S.
External linksChembiochem / PubMed:19681091
MethodsX-ray diffraction
Resolution1.7 - 2.1 Å
Structure data

PDB-3ia4:
Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-3ia5:
Moritella profunda dihydrofolate reductase (DHFR)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MTX:
METHOTREXATE / chemotherapy*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • moritella profunda (bacteria)
KeywordsOXIDOREDUCTASE / DHFR dihydrofolate reductase / NADPH / methotrexate

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