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-Structure paper
Title | Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5531-5545, Year 2009 |
Publish date | Jun 9, 2009 (structure data deposition date) |
![]() | Lumeras, W. / Caturla, F. / Vidal, L. / Esteve, C. / Balague, C. / Orellana, A. / Dominguez, M. / Roca, R. / Huerta, J.M. / Godessart, N. / Vidal, B. |
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Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-3hrb: |
Chemicals | ![]() ChemComp-I39: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / p38 MAP KINASE / INHIBITOR COMPLEX / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase |