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Structure paper

TitleEfficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 5449-5461, Year 2009
Publish dateApr 23, 2009 (structure data deposition date)
AuthorsWan, Z.K. / Chenail, E. / Xiang, J. / Li, H.Q. / Ipek, M. / Bard, J. / Svenson, K. / Mansour, T.S. / Xu, X. / Tian, X. ...Wan, Z.K. / Chenail, E. / Xiang, J. / Li, H.Q. / Ipek, M. / Bard, J. / Svenson, K. / Mansour, T.S. / Xu, X. / Tian, X. / Suri, V. / Hahm, S. / Xing, Y. / Johnson, C.E. / Li, X. / Qadri, A. / Panza, D. / Perreault, M. / Tobin, J.F. / Saiah, E.
External linksJ. Med. Chem. / PubMed:19673466
MethodsX-ray diffraction
Resolution2.187 - 2.3 Å
Structure data

PDB-3h6k:
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.187 Å

PDB-3hfg:
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-33T:
3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide

ChemComp-HOH:
WATER

ChemComp-17R:
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl}piperazine

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / HSD1 / NADP / inhibitor / Endoplasmic reticulum / Glycoprotein / Lipid metabolism / Membrane / Polymorphism / Signal-anchor / Steroid metabolism / Transmembrane

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