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Structure paper

TitleStructure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
Journal, issue, pagesMol. Biochem. Parasitol., Vol. 168, Page 158-167, Year 2009
Publish dateDec 19, 2008 (structure data deposition date)
AuthorsAlvarado, J.J. / Nemkal, A. / Sauder, J.M. / Russell, M. / Akiyoshi, D.E. / Shi, W. / Almo, S.C. / Weiss, L.M.
External linksMol. Biochem. Parasitol. / PubMed:19660503
MethodsX-ray diffraction
Resolution2.18 - 2.89 Å
Structure data

PDB-3fm3:
Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

PDB-3fmq:
Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3fmr:
Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor TNP470 bound
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-FUG:
FUMAGILLIN / Antimicrobial*YM

ChemComp-TN4:
(1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl

Source
  • encephalitozoon cuniculi (fungus)
KeywordsHYDROLASE / METHIONINE AMINOPEPTIDASE TYPE2 / METAP2 / ENCEPHALITOZOON CUNICULI / STRUCTURAL GENOMICS / PSI-2 / PROTEIN STRUCTURE INITIATIVE / New York SGX Research Center for Structural Genomics / NYSGXRC / Aminopeptidase / Cobalt / Metal-binding / Protease / METAP2 FUMAGILLIN COMPLEX / METAP2 TNP470 COMPLEX

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