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Structure paper

TitleCharacterization of two classes of small molecule inhibitors of Arp2/3 complex
Journal, issue, pagesNature, Vol. 460, Page 1031-1034, Year 2009
Publish dateJul 24, 2008 (structure data deposition date)
AuthorsNolen, B.J. / Tomasevic, N. / Russell, A. / Pierce, D.W. / Jia, Z. / McCormick, C.D. / Hartman, J. / Sakowicz, R. / Pollard, T.D.
External linksNature / PubMed:19648907
MethodsX-ray diffraction
Resolution2.7 - 2.85 Å
Structure data

PDB-3dxk:
Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3dxm:
Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-N23:
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

ChemComp-HOH:
WATER

ChemComp-N24:
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one

Source
  • bos taurus (domestic cattle)
KeywordsSTRUCTURAL PROTEIN / beta-propeller / Acetylation / Actin-binding / ATP-binding / Cell projection / Cytoplasm / Cytoskeleton / Nucleotide-binding / Phosphoprotein / WD repeat

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