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-Structure paper
Title | ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5013-5016, Year 2009 |
Publish date | Jul 15, 2009 (structure data deposition date) |
Authors | Zask, A. / Verheijen, J.C. / Curran, K. / Kaplan, J. / Richard, D.J. / Nowak, P. / Malwitz, D.J. / Brooijmans, N. / Bard, J. / Svenson, K. ...Zask, A. / Verheijen, J.C. / Curran, K. / Kaplan, J. / Richard, D.J. / Nowak, P. / Malwitz, D.J. / Brooijmans, N. / Bard, J. / Svenson, K. / Lucas, J. / Toral-Barza, L. / Zhang, W.G. / Hollander, I. / Gibbons, J.J. / Abraham, R.T. / Ayral-Kaloustian, S. / Mansour, T.S. / Yu, K. |
External links | J. Med. Chem. / PubMed:19645448 |
Methods | X-ray diffraction |
Resolution | 2.798 Å |
Structure data | PDB-3ibe: |
Chemicals | ChemComp-SO4: ChemComp-L64: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / PI3Kinase Inhibitor / ATP-binding / Kinase / Nucleotide-binding |