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TitleMechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 27629-27636, Year 2009
Publish dateJul 12, 2009 (structure data deposition date)
AuthorsGraeff, R. / Liu, Q. / Kriksunov, I.A. / Kotaka, M. / Oppenheimer, N. / Hao, Q. / Lee, H.C.
External linksJ. Biol. Chem. / PubMed:19640843
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-3i9o:
Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-AVW:
[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate

Source
  • aplysia californica (California sea hare)
KeywordsHYDROLASE / Homodimer / enzyme-reaction-intermediate complex / ADP-ribosyl cyclase / Disulfide bond / Fertilization / NAD

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