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TitleSulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 48, Page 6448-6452, Year 2009
Publish dateNov 17, 2008 (structure data deposition date)
AuthorsLee, H.J. / Wang, N.X. / Shi, D.L. / Zheng, J.J.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:19637179
MethodsNMR (solution)
Structure data

PDB-2kaw:
NMR structure of the mDvl1 PDZ domain in complex with its inhibitor
Method: SOLUTION NMR

Chemicals

ChemComp-SUZ:
[(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid / antiinflammatory*YM

Source
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / INHIBITOR OF PROTEIN-PROTEIN INTERACTIONS / PROTEIN STRUCTURE / PDZ DOMAIN / WNT SIGNALING / Developmental protein / Wnt signaling pathway

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