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TitleBenzo[c][2,7]naphthyridines as inhibitors of PDK-1
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 5225-5228, Year 2009
Publish dateApr 30, 2009 (structure data deposition date)
AuthorsKim, K.H. / Wissner, A. / Floyd, M.B. / Fraser, H.L. / Wang, Y.D. / Dushin, R.G. / Hu, Y. / Olland, A. / Guo, B. / Arndt, K.
External linksBioorg. Med. Chem. Lett. / PubMed:19628388
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3h9o:
Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-9BD:
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PDK-1 / kinase / protein structure / X-ray crysatllography / Alternative splicing / ATP-binding / Cytoplasm / Membrane / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase

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