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-Structure paper
Title | Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 4777-4780, Year 2009 |
Publish date | Feb 12, 2009 (structure data deposition date) |
![]() | Thompson, S.K. / Washburn, D.G. / Frazee, J.S. / Madauss, K.P. / Hoang, T.H. / Lapinski, L. / Grygielko, E.T. / Glace, L.E. / Trizna, W. / Williams, S.P. ...Thompson, S.K. / Washburn, D.G. / Frazee, J.S. / Madauss, K.P. / Hoang, T.H. / Lapinski, L. / Grygielko, E.T. / Glace, L.E. / Trizna, W. / Williams, S.P. / Duraiswami, C. / Bray, J.D. / Laping, N.J. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.1 Å |
Structure data | ![]() PDB-3g8o: ![]() PDB-3hq5: |
Chemicals | ![]() ChemComp-30X: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-GKK: ![]() ChemComp-GOL: |
Source |
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![]() | TRANSCRIPTION / Progesterone Receptor / Steroid Hormone Receptor / Nuclear Receptor / PR / progesterone / alpha helical sandwich / DNA-binding / Lipid-binding / Metal-binding / Nucleus / Phosphoprotein / Receptor / Steroid-binding / Transcription regulation / Zinc-finger / hormone binding protein / Alternative splicing / Cytoplasm / Isopeptide bond / Polymorphism / Ubl conjugation / Zinc |