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TitleNimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
Journal, issue, pagesCancer Res., Vol. 69, Page 5851-5859, Year 2009
Publish dateMar 11, 2009 (structure data deposition date)
AuthorsTalavera, A. / Friemann, R. / Gomez-Puerta, S. / Martinez-Fleites, C. / Garrido, G. / Rabasa, A. / Lopez-Requena, A. / Pupo, A. / Johansen, R.F. / Sanchez, O. ...Talavera, A. / Friemann, R. / Gomez-Puerta, S. / Martinez-Fleites, C. / Garrido, G. / Rabasa, A. / Lopez-Requena, A. / Pupo, A. / Johansen, R.F. / Sanchez, O. / Krengel, U. / Moreno, E.
External linksCancer Res. / PubMed:19584289
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3gkw:
Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTITUMOR PROTEIN / Immunoglobulin fold / Displaced strictly conserved TRP 103 following Kabat numbering

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