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TitleMechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 137, Page 1293-1307, Year 2009
Publish dateMar 27, 2009 (structure data deposition date)
AuthorsJura, N. / Endres, N.F. / Engel, K. / Deindl, S. / Das, R. / Lamers, M.H. / Wemmer, D.E. / Zhang, X. / Kuriyan, J.
External linksCell(Cambridge,Mass. ) / PubMed:19563760
MethodsX-ray diffraction
Resolution2.955 Å
Structure data

PDB-3gt8:
Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.955 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / inactive kinase / dimer / Alternative splicing / Anti-oncogene / ATP-binding / Cell cycle / Cell membrane / Disease mutation / Disulfide bond / Glycoprotein / Isopeptide bond / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Secreted / Transmembrane / Tyrosine-protein kinase / Ubl conjugation

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