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TitleStructural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 22467-, Year 2009
Publish dateDec 23, 2008 (structure data deposition date)
AuthorsIrimia, A. / Eoff, R.L. / Guengerich, F.P. / Egli, M.
External linksJ. Biol. Chem. / PubMed:19542228
MethodsX-ray diffraction
Resolution3.16 - 3.71 Å
Structure data

PDB-2w7o:
Structure and Activity of Bypass Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-oxodeoxyguanosine Adduct
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

PDB-2w7p:
Structure and Activity of Bypass Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-oxodeoxyguanosine Adduct
Method: X-RAY DIFFRACTION / Resolution: 3.71 Å

Chemicals

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / 8-OXO-2P-DEOXY-GUANOSINE-5P-MONOPHOSPHATE / TRANSLESION DNA POLYMERASE / HUMAN DNA POLYMERASE KAPPA / DGTP / DNA REPAIR / DNA DAMAGE / DNA-BINDING PROTEIN / DATP

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